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Despite substantial progress, UPS-based therapies face key obstacles, including achieving substrate specificity and efficient CNS delivery

The narrow arteries of the kidney including glomerular capillaries, and interlobular and arcuate arteries can be clogged by arterial cholesterol plaques following administration of thrombolytic agents (e.g., streptokinase) and anticoagulants (e.g., warfarin)

Delamanid is primarily metabolized by albumin and, to a lesser extent, by CYP3A4 in the liver

We hypothesized that, in addition to metabolic alterations, other changes were occurring in the liver of Gclc KO mice, which could explain the lack of damage in the tissue